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KMID : 0391020030110020120
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Journal of Korean Society for Clinical Pharmacology and Therapeutics
2003 Volume.11 No. 2 p.120 ~ p.127
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Comparative Study of S-Adenosylmethionine and Ibuprofen for Effectiveness and Safety in the Treatment Osteoarthritis of Knee
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Kim Dae-Sung
Kim Ho-Youn
Do Joo-Ho
Jung Young-Ok
Koh Hyek-Jae
Baek Seung-In
Lee Sang-Heon
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Abstract
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Objective : To compare the efficacy and safety of S-adenosyl-methionine (SAMe) and ibuprofen in the treatment of patients with knee osteoarthritis.
Methods : Sixty patients with knee osteoarthritis (OA) were enrolled in this study. Patients received a daily oral dose of 1200mg of SAMe and 1200mg of ibuprofen for 4 weeks Treatment efficacy was evaluated with clinical parameters as Lequesne’’s functional index and visual analog scale (VAS) of pain. Adverse effects were monitored from patient interviews and blood sampling.
Results:The treatment efficacy evaluated by clinical parameters was not different in both groups. Gastrointestinal adverse effects were more frequently observed in ibuprofen group than in SAMe.
Conclusion :SAMe was equally effective to ibuprofen in efficacy and better tolerated in short term treatment of patients with knee OA.
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KEYWORD
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SAMe, Ibubrufen, Osteoarthritis
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